Process

Thyroid hormone production

Related terms: T4 to T3 conversion, Deiodinase, Thyroxine, Triiodothyronine, Reverse T3

EstablishedTextbook physiology, or consistent findings reflected in national guidance.
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In brief

The thyroid uses iodine from food to make the hormones thyroxine (T4) and tri-iodothyronine (T3). The pituitary gland sets the pace with TSH.

  • Since 2009, manufactured bread in Australia has been made with iodised salt, according to healthdirect.
  • Not getting enough iodine is one cause of an underactive thyroid.
  • TSH is the only thyroid test covered by Medicare if you do not have a history of thyroid problems.

How it works

The thyroid needs iodine to make its hormones, and people need about 150 micrograms a day, according to the Better Health Channel. It makes mostly T4, while T3 is more active but made in smaller amounts. Your thyroid gland also needs selenium to make hormones.

The pituitary gland releases thyroid stimulating hormone (TSH), which prompts the thyroid to release more T4 and T3. When T4 is high, the pituitary makes less TSH, and when it is low, it makes more. Doctors check TSH first, and test free T4 or free T3 if TSH is abnormal.

Connections

3 connections on the map. Select a topic to read its page.

Thyroid hormone production is part of Thyroid glandThyroid glandThyroid hormone production needs IodineIodineThyroid hormone production needs SeleniumSeleniumThyroid hormone production is part of Thyroid glandThyroid glandThyroid hormone production needs IodineIodineThyroid hormone production needs SeleniumSelenium

Thyroid hormone production needs

Thyroid hormone production is part of

Lab tests

Sources

  1. Thyroid glandBetter Health Channel (Victorian Government), last reviewed 6 December 2015
  2. Thyroid function testsPathology Tests Explained, last reviewed 9 January 2025
  3. Thyroid stimulating hormone (TSH)Pathology Tests Explained, last reviewed 14 October 2025
  4. Foods high in iodinehealthdirect Australia, last reviewed April 2025
  5. Selenium fact sheet for consumersNIH Office of Dietary Supplements, last reviewed June 18, 2025
  6. Hypothyroidism (underactive thyroid)healthdirect Australia, last reviewed October 2024

Each connection above names its own source. See every source AskBioMap uses.

Summarised from the Better Health Channel, Pathology Tests Explained, healthdirect and the NIH Office of Dietary Supplements. Sources read on 13, 16 and 19 October 2026. General education only, not medical advice. Spotted a mistake? Please tell us through the HuBu-Intel contact page.

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